The Synnate program is defining the importance of host mucosal signalling pathways in resisting and restoring barrier integrity upon during homeostasis in equilibrium with the microbiome, and after disruption by infection and/or antibiotic treatment.
This will provide an exceptional knowledge gain to understand the molecular and biochemical consequences of mucosal disruption to the microbiome and the innate response, and allow us to go beyond models of association to intervention and restoration of mucosal health.
Our diverse, multi-disciplinary team will create a new paradigms, platforms and resources to promote Australia’s research capacity in host-microbiome immunology.
Prof. Paul Hertzog
Prof. Christine Wells
Prof. Liz Hartland
Dr. Sam Forster
The scale and complexity of this problem absolutely necessitates a synergistic approach. There is a huge gut surface (approx. 32m2), a few thousand different microbial species interacting with a co-evolved immune and epithelial system of highly interactive cells.
Therefore, our program has coordinated groups with scalable biology, scalable data collection, scalable data analysis and meaningful/ interpretable data representation to deliver this cutting-edge discovery science with potential for immense translatable health outcomes.
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Synnate is a partnership between the Hudson Institute of Medical Research and the University of Melbourne.